With the introduction of Guitar Hero World Tour in 2008, the game includes support for a four-player band including vocals and drums. The series initially used mostly cover version of songs created by WaveGroup Sound, but most recent titles feature soundtracks that are fullymaster recordings, and in some cases, special re-recordings, of the songs. Later titles in the series feature support for downloadable contentin the form of new songs.

In 2005, RedOctane, a company specializing in the manufacture of unique game controllers, was inspired to create Guitar Hero based on RedOctane's experience creating hardware for Konami's GuitarFreaks arcade game. They enlisted Harmonix Music Systems, who previously developed several music video games, for development assistance. The first game in the series was made on a budget of $1 million. The series became extremely successful, leading to the acquisition of RedOctane by Activision in 2007. Harmonix was acquired by MTV Games and went on to create the Rock Band series of music games in the same vein as Guitar Hero. Activision brought Neversoft (primarily known for their Tony Hawk series of skateboarding games) on board for future development duties. Additional companies, such as Vicarious Visions, Budcat Creations, Machineworks Northwest, and Aspyr Media have assisted in the adaptation of the games for other systems.